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Follow Carol as she continues to write amazing articles regarding bio-identical hormones with a focus on successful aging. Carol has read, researched, and reviewed a staggering number of books and scientific papers and attended hundreds of conferences and brings you the best and latest information on bioidentical hormones and other cutting edge therapies.
   

The Tangled Protein Theory for Alzheimer's Disease Fails


For decades, we have believed that beta-amyloid tangles in the brain caused Alzheimer’s. Unfortunately, this theory has dominated drug development and clinical trials which have come to dead ends.

Alzheimer’s is characterized early by loss of short term memory, searching for words, loss of spatial orientation, and mood swings. The brain even shrinks, particularly the hippocampus.

Insulin resistance can be a significant underlying cause. Alzheimer’s is sometimes called type 3 diabetes.

In a recent podcast, Dr Eric Berg describes another theory. He cites Dr. Michael Schrag who has received grants to study his idea that Alzheimer’s is a disease caused by lysosome dysfunction.

Lysosomes are organelles found inside the cells and are responsible for handling cell debris. Lysosomes are loaded with enzymes that facilitate the breaking down of protein. Breaking down the proteins is called autophagy (eating self) which sets the ground for new proteins to be made, basically, a recycling program. Dr Schrag believes there is a gene mutation which interferes in the ability of lysosomes to digest proteins properly.

Alzheimer’s can be a problem with autophagy in the lysosomes. Dr. Berg describes fasting as the best therapy for increasing autophagy. Fasting also lowers insulin and glucose, also involved in Alzheimer’s. He recommends one meal a day and includes a 48 hour fast once a week. There are also natural enhancers.

Here are some of Dr. Berg’s recommendations:

  • Curcumin from turmeric
  • Pine bark (Pycnogenol)
  • Thunder god vine
  • Green tea (EGCG)
  • Short chain fatty acids as produced in the microbiome.
  • Exercise
  • Sleep
  • Cruciferous foods (sulforaphane)
  • Extra virgin olive oil
  • Heat and cold therapy


Medical science often tangles itself into theories are so stratified, it becomes difficult to entertain other theories. We hang onto some theories even after multiple exceptions and failures emerge. Lysosome dysfunction is an exciting new focus for solving the Alzheimer’s problem. Alzheimer’s disease is increasing and is no longer just an old person’s malady. Inevitably, there is no magic new molecule. We already have solutions for operating our bodies effectively.

References:
Dr. Eric Berg: https://www.youtube.com/watch?v=sB6CN3yz
https://schraglab.com/lysosome-dysfunction-in-alzheimers-disease-and-caa/ https://pubmed.ncbi.nlm.nih.gov/32276321/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246646/


Recommendations:


SunSpectrum: This prebiotic formula contains guar gum to nourish a healthy microbiome. Combining this with Bifidobacterium lactis fosters a microbial source of short chain fatty acids. Adding Curcumin C3*. a particularly well absorbed curcumin and turmeric makes this product a choice for enhancing lysosome activity.

*https://c3reduct.com/curcumin-c3-reduct/introduction/
https://www.sciencedirect.com/science/article/pii/S0717345820300282


SulforaXym: https://pubmed.ncbi.nlm.nih.gov/32138578/

Teavigo:  https://pubmed.ncbi.nlm.nih.gov/34569560/

   
     

The Wellness By Design Project Recommended Products

SunSpectrum  


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SulforaXym


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Teavigo


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From The Wellness By Design Project Blog

Nitric Oxide and Hormones

Nitric oxide (NO) supports homeostasis in the endothelium. Endothelial cells are cells that line the interior surface of blood vessels or lymphatic vessels. Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries. 

 


Copper Deficiency and Iron Overload

Unraveling how and why we age is a research focus.  We are still captivated by the Ponce de Leon promise of the Fountain of Youth.  An enzyme system named mTOR (mammalian or mechanistic target of rapamycin) was identified in mouse studies as a significant aging mechanism.

     
   
   
   

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